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RESEARCH
ISOMED is undergoing continual investigation for the development of new breath test methods, to establish functional capacity of the liver, pancreas and digestive system.
Should you wish for more information regarding our ongoing scientific research, please do not hesitate to contact us.
13 C ENRICHED SUBSTRATES FOR BREATH TESTS
Liver function and related diseases
13 C-Aminopyrine
13 C-Caffeine
13 C-Erythromycin
13 C-Methacetin
13 C-Phenylalanine
as a tracer compound
In order to study the metabolism, the functional capacity of the liver and the severity of liver diseases, recently a number of breath tests have been used as a simple alternative to the existing invasive methods used up to now that measure the activity of various P450 enzymes. This compound is successfully used to monitor the inactivation of P450 enzymes of the liver.
Fat malabsorption and Pancreatic Function
13 C-Triglycerides(mixed)
13 C-Trioctanoin
13 C-Triolein
13 C-Tripalmitin
as a tracer compound
A variety of 13 C enriched substrates have been used to study fat utilization and its relationship to nutritional disorders, fat malabsorption and pancreatic insufficiency. 13 C-Trioctanoin and a mixed triglyceride of 13 C Octanoyl Distearin can provide detailed information about exocrine pancreatic function and pancreatic lipase activity. One disease which exhibits pancreatic insufficiency is Cystic Fibrosis, which has been studied using the 13 C Mixed Triglyceride.
13 C Triolein and 13 C Tripalmitin have been used to study Crohn's disease and steatorrhea.
Bacterial overgrowth
13 C - Xylose
as a tracer compound
The bacterial overgrowth occurs when the usual bacterial population that lives inside of the intestine has been eradicated through antibiotics.
As a result, other kind of bacteria that are not regularly found in the intestine take the place of the common bacteria. The results of bacterial overgrowth in the small intestine include nutrient malabsorption, weight loss and malnutrition.
The 13 C Xylose Breath Test is used for the detection of bacterial overgrowth. It can also be used for monitoring the elimination of this disorder.
Gastric Emptying
13 C - Acetate
13 C - Octanoate
as a tracer compound
13 C Breath Tests have proven useful to study the effect of drugs on gastric emptying rates. These tests are preferred over the radioscintigraphic methods currently in use. The 13 C-Octanoate Breath Test is especially useful to study the effect of the dyspepsia drugs, cisapride and octreotide, on the gastric emptying rates of solids. 13 C-Acetate can be used in a similar breath test used to study liquid emptying rates. It has also been shown, using the breath test, that patients with insulin dependent diabetes mellitus exhibit delayed gastric emptying.